The purpose of chromosome screening is to analyze to be selected in transferring normal embryo for higher successful of pregnancy and also to avoid miscarriage. It is known that aneuploidy – any embryo with too many or too few chromosomes which most likely that reason for failure in the treatment.
Preimplantation Genetic Screening (PGS), also known as aneuploidy screening, usingPGD 5 Probes and Next Generation Sequencing (NGS) is widely used to select competent embryos, free of chromosome abnormalities, for embryo transfer. This embryo selection improves clinical outcomes by achieving a higher implantation rate and a reduction in miscarriage rates.
We provide 2methods of chromosome screening.
- PGD 5 Probes – this method is to screened for the abnormality in chromosome number 13, 15, 21 and X-Y (Sex chromosome), by using FISH (Fluorescent in situ hybridization) requires removal a single cell on Day 3 or several cells on day 5 or 6 of embryo development. The FISH test is done using fluorescent probes that bind to certain specific chromosomes.
- NGS – this method is to screen for the abnormality in all humanchromosome, including X-Y chromosome (Sex chromosome). Next-Generation Sequencing (NGS) is the latest technology in genetic testing all 23 pair’sof human chromosomes and sex chromosome at a more comprehensive level and with high resolution. NGS provides the ability to screen embryos from chromosomes errors such as Down syndrome and other similar aneuploidy conditions.